
Emgality (galcanezumab) is a once-monthly CGRP monoclonal antibody that prevents migraine attacks before they start. Cardiovascular-safe, no taper, and most patients see fewer migraine days within the first month.
Look at it this way: Emgality is designed to work behind the scenes to help prevent migraines from even starting, rather than just treating them once they've already hit. This means you could see a real difference in your everyday life, with clinical studies showing people went from having about 9.1 migraine days per month down to about 4.6 days per month, which is an average reduction of 4.5 migraine days each month. Have a question on your mind? Just tap one below.
For migraine prevention, treatment begins with a 240 mg loading dose (two 120 mg injections), given once to reach therapeutic levels quickly.
Emgality works by blocking the activity of a protein called calcitonin gene-related peptide (CGRP). CGRP is known to play a key role in transmitting pain signals during migraine and cluster headache attacks.
Maintain your progress with a 120 mg injection monthly. Your Klinic care team tracks every dose and adjusts as needed.
When you start Emgality for migraine prevention, you'll first take a one-time loading dose of 240 mg, which is two 120 mg injections. This helps the medicine get to work quickly by blocking a protein called CGRP, which is involved in sending pain signals during a migraine. After that initial dose, you'll continue with a 120 mg injection once a month to keep helping prevent your migraines. Have a question on your mind? Just tap one below.

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of patients had a ≥50% reduction in migraine days
When you take Emgality, the goal is to reduce how many migraine days you experience each month. In clinical trials, about 59% of people saw their monthly migraine days cut by at least half. Keep in mind that everyone responds a little differently, so your doctor will track your progress over time and adjust your plan as needed. Have a question on your mind? Just tap one below.
Pooled EVOLVE-1 & EVOLVE-2 Phase 3 trials (episodic migraine, 120 mg monthly); Emgality (galcanezumab-gnlm) U.S. Prescribing Information.
Look at it this way: Aura symptoms like flashes of light, blind spots, zig-zag lines, or tingling can be really unsettling when they happen before or during a migraine. While Emgality doesn't directly treat the aura itself, the good news is that by reducing your total number of migraine days, you'll likely experience fewer of these aura episodes overall. Just let me know if you have any questions on your mind!
When it comes to Emgality, it's good to know a few things: You'll want to protect it from direct sunlight and let it sit at room temperature for 30 minutes before using it, making sure not to warm or shake it. If you miss a dose for migraine prevention or episodic cluster headache, just take it as soon as you remember, then adjust your monthly schedule from that new date. While it can cause changes in blood pressure, which your doctor should monitor, most people start seeing fewer migraine days within the first month, with even more improvement over 3 months. Have a question on your mind? Just tap one below.

Speak with a licensed physician and start Emgality in days, not weeks.
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